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I have researched this by asking my Pharmacist, Doctor, RN and Dietian-2 of which I work with. I was on another antibiotic and asked if I could take it. The Pharmacist and Doctor said not only could I take it with my Amoxicillin, it would make it perform better and keeps you from the nasty side effect of diarrhea. It worked! I have had lymphoma and need extra help. Buy a good one! I do NOT sell this brand but I use Ultimate Flora Critical Care.